Clickjacking is an ingenious technique for hiding an invisible <iframe> containing malicious code, but positioned on top of a thing that looks enticing to click on. The user would then be enticed into clicking on the malicious button. The frameguard module for Helmet will set a header instructing the browser on how to treat an <iframe>. For documentation, see https://helmetjs.github.io/docs/frameguard/.
app.use(helmet.frameguard({ action: 'deny' }));
This setting denies all such <iframe> content.