Genetics and Genomics

Genetics and Genomics

by Dr. Dr. Ahmad Faridi
Released June 2013
Publisher(s): Pearson Education India
ISBN: 9789332520318

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Book description

Genetics and Genomics offers basic and applied knowledge and deals with the identification, transmission, structure and function of genetic material, recombinant DNA technology, and areas related to the expression and regulation of genome. Comprising latest examples and experiments, it is useful for students studying zoology, botany, biochemistry, genetics and genomics, cytology, cytogenetics, cell ,molecular biology, toxicology, genotoxicity and environmental biology, human genetics, medical and clinical genetics, paramedical and allied sciences.

Table of contents

  1. Cover
  2. Title Page
  3. Brief Contents
  4. Contents
  5. About the Author
  6. Preface
  7. Part One: Transmission Genetics
    1. Chapter 1: Mendelian Genetics
      1. Genetic Symbols and Crossing Procedure
      2. Phenomenon of Dominance
      3. Laws of Heredity
      4. Explaining Mendelism in the Light of Chromosomal Inheritance
      5. Molecular Basis of Mendel's Work
      6. Laws of Probability and Mendelian Inheritance
      7. Mendelian Inheritance and Some Human Traits
      8. Summary
      9. Key Terms
      10. Review Questions
    2. Chapter 2: Extension and Modification of Mendel Laws and Gene Interaction
      1. Modification of Mendelian Ratios
      2. Supplementary Gene Interaction
      3. Complementary Gene Interaction
      4. Epistasis: Dominant and Recessive
      5. Molecular Basis of Gene Interaction
      6. Interaction Involving More Genes
      7. Lethal Interaction
      8. Suppressor Genes and Pseudogenes
      9. Environmental Effect on Phenotypic Expression
      10. Onset of Genetic Expression
      11. Summary
      12. Key Terms
      13. Review Questions
    3. Chapter 3: Multiple Alleles and Polygenic Inheritance
      1. Multiple Alleles in Diverse Organisms
      2. Multiple Alleles in Human Blood Groups
      3. MN Blood Group
      4. ABO Blood Group
      5. Molecular Genetics of H Antigen
      6. Genetics of Rh Factor
      7. Multiple Alleles in H-2 and HLA Systems
      8. Polygenic Inheritance and Continuous Variations
      9. Quantitative Traits
      10. Summary
      11. Key Terms
      12. Review Questions
    4. Chapter 4: Sex Determination and Differentiation
      1. Genic Sex Determination and Haploidy
      2. Chromosomal Mechanism of Sex Determination
      3. Hormones, Environmental Factors and Sex Differentiation
      4. Sex Determination in Drosophila
      5. Sex Determination in Human
      6. Gene Dosage Compensation
      7. Molecular Basis of X Inactivation
      8. Summary
      9. Key Terms
      10. Review Questions
    5. Chapter 5: Sex Linkage and Holandric Transmission
      1. Pattern of Sex-Linked Gene Transmission
      2. Sex-Linked Genes in Drosophila
      3. Sex Linkage in Humans
      4. Holandric Genes
      5. Sex-Limited and Sex-Influenced Genes
      6. Summary
      7. Key Terms
      8. Review Questions
    6. Chapter 6: Extranuclear Inheritance
      1. The Criteria of Extranuclear Inheritance
      2. Maternal Effects
      3. Infectious Heredity
      4. Organeller Heredity
      5. Chloroplast Mutants
      6. Mitochondrial Inheritance
      7. Organization of Cytoplasmic Genome
      8. Organization of Mitochondrial Genomes
      9. Mitochondrial DNA and Disorders
      10. Summary
      11. Key Terms
      12. Review Questions
  8. Part Two: Distribution of Genetic Material
    1. Chapter 7: Linkage and Crossing Over
      1. Linkage and Recombination
      2. Detection of Linkage
      3. Crossing Over and Recombination
      4. Chromosome Mapping in Drosophila
      5. Mapping and Linkage Map in Maize
      6. Tetrad Analysis and Linkage Map in Neurospora
      7. Mapping Human Chromosome
      8. Summary
      9. Key Terms
      10. Review Questions
    2. Chapter 8: Cell Mechanics and Molecular Basis of Cell Cycle
      1. Relation Between Cell Structure and Genetic Function
      2. Chromosome During Cell Division
      3. Cell Cycle Mechanics
      4. The Molecular Basis of the Cell Cycle
      5. Summary
      6. Key Terms
      7. Review Questions
    3. Chapter 9: The Events of M Phase
      1. An Overview of Mitosis
      2. Prophase
      3. Prometaphase and Metaphase
      4. Anaphase
      5. Telophase and Cytokinesis
      6. Genes Affecting Mitosis
      7. Significance of Mitosis
      8. An Overview of Meiosis
      9. First Meiotic Division
      10. Second Meiotic Division
      11. Meiosis and Regulation of Oocytes
      12. Genetic Variations
      13. Comparison of Mitosis and Meiosis
      14. Summary
      15. Key Terms
      16. Review Questions
    4. Chapter 10: Structural Organization and Special Types of Chromosomes
      1. Discovery of Chromosomes
      2. Structural Organization of Chromosomes
      3. Euchromatin and Heterochromatin
      4. Folded Fibre Hypothesis
      5. Karyotype
      6. Summary
      7. Key Terms
      8. Review Questions
    5. Chapter 11: Changes in Arrangement and Chromosome Number
      1. Structural Chromosomal Aberrations
      2. Aneuploidy: Variations in the Number of Chromosomes
      3. Polyploidy
      4. Chromosomal Evolution of Wheat and Cotton Endopolyploidy
      5. Endopolyploidy
      6. Summary
      7. Key Terms
      8. Review Questions
  9. Part Three: Structural and Functional Aspects of Genetic Material
    1. Chapter 12: Nucleic Acids and Chromatin
      1. Search for the Genetic Material
      2. Chemistry of Nucleic Acids
      3. Watson and Crick Model
      4. Structural Variants of Nucleic Acids
      5. Analytical Techniques to Investigate DNA and RNA
      6. Chromatin Structure
      7. Summary
      8. Key Terms
      9. Review Questions
    2. Chapter 13: DNA Replication and Fidelity
      1. Replication Models
      2. Experiments Demonstrating Semi-Conservative Replication
      3. Enzymes and Helping Proteins
      4. DNA Replication Process
      5. Concurrent Replication on Both Strands
      6. Replication in Closed Circular DNA
      7. Summary
      8. Key Terms
      9. Review Questions
    3. Chapter 14: Mutation, Molecular Mechanism and DNA Repair
      1. Genetic Variation and Environmental Influences
      2. Classifying Mutations
      3. Detection of Mutations
      4. Molecular Mechanism of Mutations
      5. DNA Repair Mechanisms
      6. Summary
      7. Key Terms
      8. Review Questions
  10. Part Four: Genome Expression
    1. Chapter 15: Genome Expression RNA Synthesis and Processing
      1. Flow of Genetic Information
      2. Transcription in Prokaryotes
      3. Transcription in Eukaryotes
      4. Transcription Process in Eukaryotes
      5. Post-Transcriptional Modifications and mRNA Processing
      6. Splicing Mechanisms
      7. Summary
      8. Key Terms
      9. Review Questions
    2. Chapter 16: Genome Expression Translation and Proteins
      1. Transporting mRNA in the Cytoplasm
      2. Translational Machinery
      3. Structure and Function of the Ribosomes
      4. Translating Genetic Information
      5. Post-Translational Modifications of Proteins
      6. Summary
      7. Key Terms
      8. Review Questions
    3. Chapter 17: Regulation of Genome Expression
      1. Regulation of Genome Expression in Prokaryotes
      2. Regulation of Genome Expression in Eukaryotes
      3. Transcriptional Activators
      4. Eukaryotic Repressors
      5. Regulatory RNAs
      6. Summary
      7. Key Terms
      8. Review Questions
    4. Chapter 18: Cloning and Recombinant DNA Technology
      1. Gene Transfer Methods
      2. Tools of DNA Cloning
      3. Cloning of Foreign Genes and their Identification
      4. Cloning in a Eukaryotic Host
      5. DNA Libraries
      6. Cloning Without Host Cells
      7. Transgenomics and Genetically Modified Organisms
      8. Genetic Engineering in Plants
      9. DNA Patenting
      10. Summary
      11. Key Terms
      12. Review Questions
  11. Part Five: Applied Genetics
    1. Chapter 19: Human Genetics
      1. Karyotype in Man
      2. Inherited Disorders and Chromosomal Aberrations
      3. Inborn Errors of Metabolisms
      4. Single-Gene Disorder
      5. Genetic Diseases and Amelioration
      6. Human Genome Organization
      7. Summary
      8. Key Terms
      9. Review Questions
    2. Chapter 20: Population Genetics
      1. Population, Gene Frequencies and Gene Pool
      2. The Hardy–Weinberg Law
      3. Applications of Hardy–Weinberg Law
      4. Extension of Hardy–Weinberg Law
      5. Summary
      6. Key Terms
      7. Review Questions
  12. Copyright
  13. Back Cover

Product information

  • Title: Genetics and Genomics
  • Author(s): Dr. Dr. Ahmad Faridi
  • Release date: June 2013
  • Publisher(s): Pearson Education India
  • ISBN: 9789332520318