Indeed.com says the have more than 2 million current job listings indexed so...
Apart from generic searching of their job index - which they say covers jobs from all the major job boards, newspapers and corporate web sites, you can also use their XML interface to do queries of their index directly and do with the results as you may!
You can sign up for an API key here.
Once you have that you can either construct your own enquiries or use the API tools interface here to create them for you.
You can get an overview of jobs where you live - like I was able to find 6,244 jobs with 'programming' in the job description within 50 miles of where I live. Then you can go back and narrow down your search.
You can also do more broad research into job trends like the one done here.
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Indeed XML Interface