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Cancer Clinical Trials Center -- News Archive

12/00 Phase II Clinical Trials. Phase II clinical trials aim to discover whether a treatment is effective against cancer. Some people regard this phase of the treatment testing process as the best avenue for cancer patients considering a clinical trial. Here are considerations to bear in mind about Phase II trials.
12/00 A Treatment Controversy: High-Dose Chemotherapy. When cancer patients are candidates for controversial treatments, it can be difficult to decide whether to participate. Stories in this article of how patients approached one such treatment for breast cancer are instructive for patients dealing with other types of cancer, as well. This article is derived from Musa Mayer's book Advanced Breast Cancer: A Guide to Living with Metastatic Disease, 2nd Edition, © 2001 by Musa Mayer.
12/00 The Investigator's Responsibilities. In some ways, the interests of physicians conducting clinical trials and patients enrolling in trials are in conflict. Although most physician-investigators conduct themselves with the highest level of personal and professional ethics, it's important to consider your options carefully.
11/00 Interview with the Author. Robert Finn graduated from the University of Chicago with an A.B. in biological sciences. After several years in graduate school at the University of California, Irvine, he realized that he preferred writing about science to actually doing it. Robert left with an M.S. degree to pursue a career as a science writer. He has worked in this capacity at the California Institute of Technology (Caltech) and as a freelance writer specializing in biomedicine and in science policy. Robert has been fascinated with the drug development process and clinical trials since college and has written chapters for highly technical books intended for scientists interested in clinical trails.
11/00 Phase I Clinical Trials. Phase I clinical trials are used to determine how toxic a new treatment is, the maximum tolerated dose, and the best way to administer it. There are particular advantages and disadvantages you should be aware of in connection with Phase I trials.
10/00 The Structure of Clinical Trials. Clinical trials of new cancer treatments are conducted in steps called phases, which successively determine whether the treatment is safe, effective, better than present treatments, and not harmful when used in the general population.
10/00 Clinical Trials for Children. Though cancer in children is relatively uncommon, some 81 percent of children with cancer seen at the Pediatric Oncology Group's member institutions in 1997 were enrolled in clinical trials. In contrast, the National Cancer Institute estimates that less than 5 percent of adults with cancer participate in clinical trials. This article is derived from Honna Janes-Hodder and Nancy Keene's book Childhood Cancer: A Parent's Guide to Solid Tumor Cancers, © 2001 by O'Reilly & Associates, Inc.
10/00 Clinical Trial Ethics. Clinical trials, in one form or another, have occurred for perhaps thousands of years. In recent decades, however, ethics have been formalized and codes of rules adopted to prevent the exploitation of patients.
9/00 Financial Issues. Clinical trials constitute a significant part of the rapidly increasing cost of drug development. If your insurance company won't pay the routine medical costs involved in clinical trials, there are alternative funding sources as well as agencies that can help you with expenses for travel to distant clinical trials.
9/00 The Administration of Clinical Trials. If you are considering a clinical trial, it is important to understand who manages it and what roles various participants have in running trials.
9/00 Examining the Protocol Document. Knowing the implications of statements in a clinical trial's protocol document can help you decide whether you want to participate. Here's what to look for as well as questions to ask.
9/00 Inclusion and Exclusion Criteria. When you locate a clinical trial for your cancer, find out whether you meet the inclusion criteria and ensure that the exclusion criteria don't disqualify you.

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